与对照组相比，采用无火焰原子吸收分光光度法测定的肌萎缩侧索硬化症患者血浆铅水平升高。
Increased plasma levels of lead in patients with amyotrophic lateral sclerosis compared with control subjects as determined by flameless atomic absorption spectrophotometry.
作者信息
Conradi S, Ronnevi L O, Vesterberg O
出版信息
J Neurol Neurosurg Psychiatry. 1978 May;41(5):389-93. doi: 10.1136/jnnp.41.5.389.
Abstract
The levels of lead in plasma were determined in 16 cases of amyotrophic lateral sclerosis (ALS) and 18 control subjects, using flameless atomic absorption spectrophotometry. The mean values were 0.52+/-0.22 microgram/100ml (ALS) and 0.37+/-0.13 microgram/100ml (controls), the difference is statistically significant (5% level). The values in both groups are lower than reported earlier for normal subjects. The findings are discussed against the background of the possible pathogenetic significance of retrograde axoplasmic flow in ALS.
摘要
采用无火焰原子吸收分光光度法测定了16例肌萎缩侧索硬化症（ALS）患者和18名对照者血浆中的铅含量。ALS组平均值为0.52±0.22微克/100毫升，对照组为0.37±0.13微克/100毫升，差异具有统计学意义（5%水平）。两组的值均低于先前报道的正常受试者的值。结合ALS中逆行轴浆运输可能的致病意义这一背景对这些发现进行了讨论。
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