Jenkins J M, Anthony F W, Lee A, Masson G M, Thomas E
Department of Obstetrics and Gynaecology, University of Southampton, Princess Anne Hospital, UK.
Clin Endocrinol (Oxf). 1994 Mar;40(3):357-9. doi: 10.1111/j.1365-2265.1994.tb03931.x.
This study assessed whether functional ovarian cysts may prevent suppression of serum oestradiol levels even after pituitary desensitization had been achieved with buserelin.
Of 288 in-vitro fertilization (IVF) cycles studied 10 patients were found to have cysts with serum oestradiol levels > 200 pmol/l despite 3 weeks of buserelin.
The 10 patients with cysts were given 0.1 mg GnRH and serum gonadotrophins were measured at time 0, 30 and 60 minutes subsequently. Immediately following the GnRH stimulation test the cysts were aspirated transvaginally under ultrasound guidance. Serum oestradiol levels were again measured 3 days after cyst aspiration.
Basal LH and FSH levels were < 3 U/l and there was no significant rise in response to GnRH. On the day of cyst aspiration serum oestradiol levels varied between 244 and 1127 pmol/l, and in all cases serum oestradiol levels fell to < 200 pmol/l within 3 days of cyst aspiration.
In the presence of a functional ovarian cyst, failure to suppress the serum oestradiol level does not necessarily imply a failure of pituitary desensitization with a GnRH agonist.
本研究评估功能性卵巢囊肿是否即使在使用布舍瑞林实现垂体脱敏后仍可阻止血清雌二醇水平的抑制。
在研究的288个体外受精（IVF）周期中，发现10例患者尽管使用布舍瑞林3周，但囊肿患者的血清雌二醇水平>200 pmol/l。
给10例有囊肿的患者注射0.1 mg促性腺激素释放激素（GnRH），随后在0、30和60分钟时测量血清促性腺激素。在GnRH刺激试验后立即在超声引导下经阴道抽吸囊肿。在囊肿抽吸后3天再次测量血清雌二醇水平。
基础促黄体生成素（LH）和促卵泡生成素（FSH）水平<3 U/l，对GnRH的反应无显著升高。在囊肿抽吸当天，血清雌二醇水平在244至1127 pmol/l之间变化，并且在所有病例中，血清雌二醇水平在囊肿抽吸后3天内降至<200 pmol/l。
在存在功能性卵巢囊肿的情况下，未能抑制血清雌二醇水平不一定意味着GnRH激动剂垂体脱敏失败。
