急性诱导高血压状态下狒狒脑循环的研究

Studies on the cerebral circulation of the baboon in acutely induced hypertension.

作者信息

Strandgaard S, MacKenzie E T, Jones J V, Harper A M

出版信息

Stroke. 1976 May-Jun;7(3):287-90. doi: 10.1161/01.str.7.3.287.

DOI:10.1161/01.str.7.3.287

Abstract

The upper limit autoregulation of cerebral blood flow was investigated in eight young baboons with the intracarotid 133xenon clearance method. Blood pressure was increased by intravenous angiotensin infusion. Autoregulation was effective during blood pressure increase from normotensive levels to a mean pressure of 130 to 139 mm Hg. At this pressure, cerebrovascular resistance reached a maximum. With further blood pressure increase, autoregulation was broken, and the vascular resistance dropped significantly. This flow increase was restricted to the fast component of the 133xenon clearance curve, leaving slow component unchanged.

摘要

采用颈内动脉133氙清除法对8只幼年狒狒的脑血流自动调节上限进行了研究。通过静脉输注血管紧张素使血压升高。在血压从正常水平升至平均压130至139毫米汞柱的过程中，自动调节有效。在此血压水平时，脑血管阻力达到最大值。随着血压进一步升高，自动调节被打破，血管阻力显著下降。这种血流增加仅限于133氙清除曲线的快速成分，而慢速成分保持不变。