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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Awasthi Y C, Sharma R, Singhal S S

Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77555-1067.

Int J Biochem. 1994 Mar;26(3):295-308. doi: 10.1016/0020-711x(94)90050-7.

Multiple forms of glutathione S-transferase (GST) isoenzymes present in human tissues are dimers of subunits belonging to three distinct gene families namely alpha, mu and pi. Only the subunits within each class hybridize to give active dimers. 2. These subunits are differentially expressed in a tissue-specific manner and the composition of glutathione S-transferases in various tissues differs significantly. 3. Minor GST subunits not belonging to these three classes are also present in some tissues. 4. An ortholog of rat GST 8-8 and mouse mGSTA4-4 is selectively expressed in some human tissues including bladder, brain, heart, liver, and pancreas. This isoenzyme designated as GST 5.8 expresses several fold higher activity towards 4-hydroxy-2,3-trans-nonenal as compared to the routinely used substrate 1-chloro-2,4-dinitrobenzene.

人类组织中存在的多种形式的谷胱甘肽S-转移酶（GST）同工酶是属于三个不同基因家族（即α、μ和π）的亚基二聚体。只有每个类别中的亚基杂交才能产生活性二聚体。2. 这些亚基以组织特异性方式差异表达，不同组织中谷胱甘肽S-转移酶的组成差异显著。3. 不属于这三类的次要GST亚基在某些组织中也存在。4. 大鼠GST 8-8和小鼠mGSTA4-4的直系同源物在包括膀胱、脑、心脏、肝脏和胰腺在内的一些人类组织中选择性表达。这种同工酶被命名为GST 5.8，与常规使用的底物1-氯-2,4-二硝基苯相比，它对4-羟基-2,3-反式壬烯醛的活性高几倍。

Awasthi Y C, Sharma R, Singhal S S

Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77555-1067.

Int J Biochem. 1994 Mar;26(3):295-308. doi: 10.1016/0020-711x(94)90050-7.

Multiple forms of glutathione S-transferase (GST) isoenzymes present in human tissues are dimers of subunits belonging to three distinct gene families namely alpha, mu and pi. Only the subunits within each class hybridize to give active dimers. 2. These subunits are differentially expressed in a tissue-specific manner and the composition of glutathione S-transferases in various tissues differs significantly. 3. Minor GST subunits not belonging to these three classes are also present in some tissues. 4. An ortholog of rat GST 8-8 and mouse mGSTA4-4 is selectively expressed in some human tissues including bladder, brain, heart, liver, and pancreas. This isoenzyme designated as GST 5.8 expresses several fold higher activity towards 4-hydroxy-2,3-trans-nonenal as compared to the routinely used substrate 1-chloro-2,4-dinitrobenzene.

人类组织中存在的多种形式的谷胱甘肽S-转移酶（GST）同工酶是属于三个不同基因家族（即α、μ和π）的亚基二聚体。只有每个类别中的亚基杂交才能产生活性二聚体。2. 这些亚基以组织特异性方式差异表达，不同组织中谷胱甘肽S-转移酶的组成差异显著。3. 不属于这三类的次要GST亚基在某些组织中也存在。4. 大鼠GST 8-8和小鼠mGSTA4-4的直系同源物在包括膀胱、脑、心脏、肝脏和胰腺在内的一些人类组织中选择性表达。这种同工酶被命名为GST 5.8，与常规使用的底物1-氯-2,4-二硝基苯相比，它对4-羟基-2,3-反式壬烯醛的活性高几倍。