Yang T J, Roberts R S, Jones J B
Virchows Arch B Cell Pathol. 1976 Apr 29;20(3):197-204. doi: 10.1007/BF02890339.
Lymphoreticular cell (LRC) infiltration into tumour masses at different stages of growth after transplantation was studied in canine transmissible venereal sarcoma (CTVS). The percent viable LRC of total viable cells in tumour suspensions shows an inverse correlation with the logs of tumour mass of adult dogs (R = -0.475, phi = 28, P less than 0.01), which suggests that the degree of LRC infiltration is a measure of the host immune response. However, an estimate of the surface area (S.A.) of the tumour rather well perfused with blood elements based on the formula S.A. = 5.43 (tumour mass in g)2/3 showed that the LRC mass present in a tumour was a function of its surface area. Thus, the inverse correlation of the percent viable LRC's in a viable tumour cell suspension to the log of the CTVS mass might not necessarily indicate that the infiltrated LRC's were active as immune effector cells. The correlation does show that, as the CTVS size increases, the volume of the necrotic center increases more rapidly than the volume perfused with blood and, therefore, the percent viable LRC's in CTVS decreases with CTVS size increase.
在犬传染性性病肉瘤（CTVS）中，研究了移植后不同生长阶段肿瘤块中的淋巴网状细胞（LRC）浸润情况。肿瘤悬液中活LRC占总活细胞的百分比与成年犬肿瘤块的对数呈负相关（R = -0.475，φ = 28，P < 0.01），这表明LRC浸润程度是宿主免疫反应的一种度量。然而，根据公式表面积（S.A.）= 5.43（肿瘤质量，单位：g）2/3对血液灌注良好的肿瘤表面积（S.A.）进行估算，结果显示肿瘤中存在的LRC质量是其表面积的函数。因此，活肿瘤细胞悬液中活LRC百分比与CTVS质量对数的负相关不一定表明浸润的LRC作为免疫效应细胞是活跃的。这种相关性确实表明，随着CTVS大小增加，坏死中心的体积比血液灌注的体积增加得更快，因此，CTVS中活LRC的百分比随CTVS大小增加而降低。
