Kennedy J R, Yang T J, Allen P L
Br J Cancer. 1977 Sep;36(3):375-85. doi: 10.1038/bjc.1977.203.
The structure of canine transmissible venereal sarcoma (CTVS) has been examined from 14 to 71 days after implantation. During early growth, the tumour appears to be composed primarily of loosely arranged, round cells and a few fibroblast-like cells. As the tumour mass increases, the round cells become tightly packed with highly interdigitating plasma membranes. The number of irregularly shaped round cells and fibroblast-like cells increases with increasing tumour mass. Collagen and reticular fibres can be found in early tumours, frequently in association with the round cells, and in regions devoid of fibroblast-like cells. During tumour regression, cellular degradation is evident in fibroblast-like and irregularly shaped cells as well as round cells. The data suggest that transformation may occur in the course of tumour growth, causing morphological change from round to fibroblast-like cells, and that CTVS is an undifferentiated round-cell sarcoma capable of differentiation in a fibroblastic direction. Also present, primarily in tumour cells from newborn dogs, are cytoplasmic lamellar arrays and crystalline virus-like structures, both previously described in other forms of tumor cells.
对犬传染性性病肉瘤（CTVS）植入后14至71天的结构进行了检查。在早期生长阶段，肿瘤似乎主要由排列松散的圆形细胞和一些成纤维细胞样细胞组成。随着肿瘤块增大，圆形细胞紧密堆积，质膜高度交错。不规则形状的圆形细胞和成纤维细胞样细胞的数量随着肿瘤块的增大而增加。在早期肿瘤中可发现胶原纤维和网状纤维，它们常与圆形细胞相关，且存在于没有成纤维细胞样细胞的区域。在肿瘤消退过程中，成纤维细胞样细胞、不规则形状的细胞以及圆形细胞中均明显出现细胞降解。数据表明，在肿瘤生长过程中可能发生转化，导致细胞形态从圆形变为成纤维细胞样，并且CTVS是一种能够向成纤维细胞方向分化的未分化圆形细胞肉瘤。同样主要存在于新生犬肿瘤细胞中的还有细胞质层状排列和晶体样病毒结构，这两者先前在其他形式的肿瘤细胞中已有描述。
