Jensen O A, Johansen S, Kiss K
Eye Pathology Institute, University of Copenhagen, Denmark.
Graefes Arch Clin Exp Ophthalmol. 1994 Mar;232(3):148-52. doi: 10.1007/BF00176784.
A case is presented of an intraocular T-cell lymphoma mimicking a ring melanoma of the iris and being the first manifestation of systemic disease. A 51-year-old woman was referred with an anterior uveitis, initially presenting as a granulomatous iritis. Nodules had developed in the circumference and the lesion now imitated a malignant melanoma of the iris, which was also the diagnosis from a biopsy specimen with routine staining. Clinical, haematological and serological examination revealed no other symptoms or signs. Lymphocytic markers applied to the biopsy specimen and to the enucleated eye revealed a highly malignant T-cell lymphoma infiltrating the iris, ciliary body, anterior choroid, retina and the adjacent vitreous body. Further examination later showed T-cell lymphoma in the bone marrow, the only other organ involved. The patient died in a leukaemic phase about 1 year after the first admission. Previous cases of T-cell lymphoma with ocular involvement are reviewed.
本文报告一例眼内T细胞淋巴瘤，其表现类似虹膜环状黑色素瘤，且为系统性疾病的首发表现。一名51岁女性因前葡萄膜炎就诊，最初表现为肉芽肿性虹膜炎。虹膜周边出现结节，病变现类似虹膜恶性黑色素瘤，常规染色的活检标本诊断结果也是如此。临床、血液学和血清学检查未发现其他症状或体征。对活检标本和摘除眼球进行淋巴细胞标志物检测，结果显示为高度恶性的T细胞淋巴瘤，浸润虹膜、睫状体、脉络膜前部、视网膜及相邻玻璃体。进一步检查后来发现骨髓中也存在T细胞淋巴瘤，这是唯一受累的其他器官。患者在首次入院约1年后死于白血病期。文中还回顾了既往有眼部受累的T细胞淋巴瘤病例。
