[Disturbances in carbohydrate and fat metabolism in rats during aging, permanent estrus and the administration of DMBA].

In old female rats there was revealed an impaired tolerance to carbohydrates a decreased sensitivity to insulin and an impaired regulation of the level of nonesterified fatty acids in blood under the glucose loading. These alterations could be observed already in young rats, while inducing the persistent estrus by autoimplantation of the ovary into the tail after ovariectomy and in DMBA injection. In old rats with the induced persistent estrus a diabetic character of the sugar curve was noted. The data obtained indicate an increased threshold of the hypothalamus sensitivity to homeostatic inhibition with glucose in rats in ageing, an experimentally induced persistent estrus and the carcinogen injection.