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人类乳腺癌细胞中存在与小鼠乳腺肿瘤病毒相关的抗原,而正常乳腺上皮细胞中则不存在该抗原。

Presence of a mouse mammary tumor virus-related antigen in human breast carcinoma cells and its absence from normal mammary epithelial cells.

作者信息

Yang N S, McGrath C M, Furmanski P

出版信息

J Natl Cancer Inst. 1978 Nov;61(5):1205-8. doi: 10.1093/jnci/61.5.1205.

DOI:10.1093/jnci/61.5.1205
PMID:81881
Abstract

Antigen(s) related to the major external glycoprotein (gp52) of mouse mammary tumor virus was detected in the human breast cancer cell line MCF-7. No such antigenic determinants were detectable in normal human mammary epithelial cells.

摘要

在人乳腺癌细胞系MCF-7中检测到与小鼠乳腺肿瘤病毒主要外糖蛋白(gp52)相关的抗原。在正常人乳腺上皮细胞中未检测到此类抗原决定簇。

相似文献

1
Presence of a mouse mammary tumor virus-related antigen in human breast carcinoma cells and its absence from normal mammary epithelial cells.人类乳腺癌细胞中存在与小鼠乳腺肿瘤病毒相关的抗原,而正常乳腺上皮细胞中则不存在该抗原。
J Natl Cancer Inst. 1978 Nov;61(5):1205-8. doi: 10.1093/jnci/61.5.1205.
2
Protein A assay for mouse mammary tumor virus gp52 determinants on murine and human mammary tumor cells.用于检测小鼠和人乳腺肿瘤细胞上小鼠乳腺肿瘤病毒gp52决定簇的蛋白A分析
Virology. 1981 Jun;111(2):656-61. doi: 10.1016/0042-6822(81)90366-4.
3
Human breast carcinoma antigen is immunologically related to the polypeptide of the group-specific glycoprotein of mouse mammary tumor virus.人乳腺癌抗原在免疫上与小鼠乳腺肿瘤病毒的群特异性糖蛋白的多肽相关。
Proc Natl Acad Sci U S A. 1979 May;76(5):2460-4. doi: 10.1073/pnas.76.5.2460.
4
Specificity of the simultaneous cell-mediated immune reactivity to RIII murine mammary tumor virus glycoprotein 55 and human breast cancer tissues.对RIII鼠乳腺肿瘤病毒糖蛋白55和人乳腺癌组织的同步细胞介导免疫反应性的特异性
Cancer Res. 1978 Oct;38(10):3414-20.
5
Expression of murine mammary tumor virus-related antigens in human breast carcinoma (MCF-7) cells.鼠乳腺肿瘤病毒相关抗原在人乳腺癌(MCF - 7)细胞中的表达。
J Natl Cancer Inst. 1977 Nov;59(5):1357-67. doi: 10.1093/jnci/59.5.1357.
6
[Expression of antigens related to structural protein antigens of MMTV in breast cancer cells].[乳腺癌细胞中与小鼠乳腺肿瘤病毒结构蛋白抗原相关的抗原表达]
Vopr Onkol. 1985;31(7):47-53.
7
Detection of cell-mediated immune reactivity of breast cancer patients by the leukocyte adherence inhibition response to MCF-7 extracts.通过对MCF-7提取物的白细胞黏附抑制反应检测乳腺癌患者的细胞介导免疫反应性。
Cancer Res. 1978 Nov;38(11 Pt 1):3590-4.
8
Murine mammary tumor virus related antigen in human male mammary carcinoma.人类男性乳腺癌中的鼠乳腺肿瘤病毒相关抗原
Cancer. 1983 Feb 15;51(4):654-61. doi: 10.1002/1097-0142(19830215)51:4<654::aid-cncr2820510418>3.0.co;2-v.
9
Possible diagnostic implications of a mammary tumor virus related protein in human breast cancer.一种与乳腺肿瘤病毒相关的蛋白质在人类乳腺癌中的可能诊断意义。
Cancer. 1980 Aug 15;46(4 Suppl):879-92. doi: 10.1002/1097-0142(19800815)46:4+<879::aid-cncr2820461306>3.0.co;2-i.
10
Expression of proteins immunologically related to murine mammary tumour virus (MMTV) core proteins in the cells of breast cancer continuous lines MCF-7, T47D, MDA-231 and cells from human milk.与鼠乳腺肿瘤病毒(MMTV)核心蛋白免疫相关的蛋白质在乳腺癌连续细胞系MCF-7、T47D、MDA-231以及人乳汁细胞中的表达。
Acta Virol. 1989 Mar;33(2):137-42.

引用本文的文献

1
Naturally occurring B-cell responses to breast cancer.对乳腺癌的天然B细胞反应。
Cancer Immunol Immunother. 2003 Dec;52(12):715-38. doi: 10.1007/s00262-003-0409-4. Epub 2003 Aug 15.
2
Absence of fibronectin and presence of plasminogen activator in both normal and malignant human mammary epithelial cells in culture.培养的正常和恶性人乳腺上皮细胞中纤连蛋白的缺失及纤溶酶原激活物的存在。
J Cell Biol. 1980 Jan;84(1):120-30. doi: 10.1083/jcb.84.1.120.
3
A human protein related to the major envelope protein of murine mammary tumor virus: identification and characterization.
一种与鼠乳腺肿瘤病毒主要包膜蛋白相关的人类蛋白质:鉴定与特性分析。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1301-5. doi: 10.1073/pnas.77.3.1301.
4
Characterization of a protein, released by the T47D cell line, immunologically related to the major envelope protein of mouse mammary tumor virus.
Proc Natl Acad Sci U S A. 1985 Mar;82(5):1531-5. doi: 10.1073/pnas.82.5.1531.
5
A human breast tumor cell line (BT-474) that supports mouse mammary tumor virus replication.一种支持小鼠乳腺肿瘤病毒复制的人乳腺肿瘤细胞系(BT - 474)。
In Vitro. 1979 Sep;15(9):723-9. doi: 10.1007/BF02618252.