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Characterization of a protein, released by the T47D cell line, immunologically related to the major envelope protein of mouse mammary tumor virus.

作者信息

Segev N, Hizi A, Kirenberg F, Keydar I

出版信息

Proc Natl Acad Sci U S A. 1985 Mar;82(5):1531-5. doi: 10.1073/pnas.82.5.1531.

DOI:10.1073/pnas.82.5.1531
PMID:2983349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC397297/
Abstract

The T47D human mammary adenocarcinoma cell line in vitro releases viral particles as well as soluble proteins. Both fractions were shown to contain antigens that immunologically crossreact with the major glycoprotein (gp52) of mouse mammary tumor virus. The crossreacting antigens are located on polypeptides with apparent molecular weights of about 68,000 and 60,000. The larger one is present in viral particles whereas both are found in the soluble fraction. Both proteins are glycosylated. The human tissue culture proteins differ from gp52 not only in molecular weight but also in charge heterogenity and in polypeptide profiles obtained after partial proteolysis. The results suggest that there is a restricted similarity between MMTV gp52 and the immunologically related T47D proteins.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/8e6c9a7e6cad/pnas00345-0244-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/123c01a6b51b/pnas00345-0242-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/ea8fea9dd2b1/pnas00345-0243-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/5c22a6439925/pnas00345-0243-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/1323f610029a/pnas00345-0243-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/330f2e9c1105/pnas00345-0243-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/ec152bec597d/pnas00345-0244-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/b8eb1db395cc/pnas00345-0244-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/dbd2926ebcd1/pnas00345-0244-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/382d7c29f765/pnas00345-0244-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/8e6c9a7e6cad/pnas00345-0244-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/123c01a6b51b/pnas00345-0242-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/ea8fea9dd2b1/pnas00345-0243-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/5c22a6439925/pnas00345-0243-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/1323f610029a/pnas00345-0243-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/330f2e9c1105/pnas00345-0243-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/ec152bec597d/pnas00345-0244-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/b8eb1db395cc/pnas00345-0244-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/dbd2926ebcd1/pnas00345-0244-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/382d7c29f765/pnas00345-0244-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52a2/397297/8e6c9a7e6cad/pnas00345-0244-e.jpg

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引用本文的文献

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