Tonthat H, Rochant H, Henry A, Leporrier M, Dreyfus B
Vox Sang. 1976;30(6):464-8. doi: 10.1111/j.1423-0410.1976.tb02852.x.
A new case of cold agglutinin disease in a patient who had a long lasting Raynaud's phenomenon without hemolysis and a persistent HB antigen cirrhosis, is reported. The cold agglutinin is a monoclonal IgA kappa antibody which reacts at 4degreesC to a titer of 256. As the three other cases described in the literature, it demonstrates Pr1 specificity. The eluate from human cells reacts with rat and dog cells whose receptor is destroyed by both papain and neuraminidase, thus eliciting the characteristic Pr1d specificity.
报告了一例新的冷凝集素病患者，该患者长期患有雷诺现象但无溶血，且患有持续性乙肝抗原性肝硬化。冷凝集素是一种单克隆IgA κ抗体，在4℃时反应效价为256。与文献中描述的其他三例病例一样，它表现出Pr1特异性。从人细胞中洗脱的物质与大鼠和狗细胞反应，其受体被木瓜蛋白酶和神经氨酸酶破坏，从而引发特征性的Pr1d特异性。
