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The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12.

作者信息

Deloukas P, Dauwerse J G, van Ommen G J, van Loon A P

机构信息

Biotechnology Section, F. Hoffmann-La Roche Ltd, Basel, Switzerland.

出版信息

Genomics. 1994 Feb;19(3):592-4. doi: 10.1006/geno.1994.1115.

DOI:10.1006/geno.1994.1115
PMID:8188306
Abstract

A YAC clone that contains the human gene NFKB3, encoding the p65 subunit of transcription factor nuclear factor kappa B (NF-kappa B), was isolated. The YAC contains the entire NFKB3 gene, which is smaller than 15 kb and present in a single copy in the genome. Fluorescence in situ hybridization with metaphase chromosomes showed two different chromosomal locations (11q12 and Xp11.4) for sequences present in the YAC. The NFKB3 gene was assigned to chromosome 11q12 by PCR analysis of a panel of relevant hybrid cell lines. Thus, no linkage exists between NFKB3 and genes encoding other known members of the NF-kappa B family.

摘要

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