Eneroth C M, Lundberg C
Acta Otolaryngol. 1976 May-Jun;81(5-6):475-83. doi: 10.3109/00016487609107503.
The antibacterial effect of antibiotic treatment in maxillary sinusitis has been assessed by studying the elimination of bacteria from the maxillary sinus during treatment with penicillin and tetracycline. As adequate antibiotic concentrations are the prerequisite for maximal antibacterial effect, the antibiotic concentrations were controlled. The antibiotic concentrations were determined in maxillary sinus secretions and/or mucosas of 113 patients with maxillary sinusitis, treated with single or repeated doses of penicillin or tetracycline, or the two antibiotics in combination. In 30 patients treated with either penicillin or tetracycline, the bacterial growth in sinus secretion was controlled before and after treatment. It was established that ordinary clinical doses of penicillin and tetracycline may, although not invariably, result in antibiotic concentrations in sinus secretion and sinus mucosa than can be regarded as adequate for treatment, i.e. for penicillin greater than or equal to 0.25 mug/ml and for tetracycline greater than or equal to 1.0 mug/ml. The necessity of achieving adequate antibiotic concentrations in sinus secretion and sinus mucosa to ensure therapeutic success was demonstrated. Thus, bacterial growth remained in the secretions of most maxillary sinuses when the concentrations of penicillin or tetracycline in the secretions were not regarded as adequate for treatment. In contrast, the bacteria were exterminated in most cases where concentrations were regarded as adequate.
通过研究青霉素和四环素治疗期间上颌窦内细菌的清除情况，评估了抗生素治疗上颌窦炎的抗菌效果。由于足够的抗生素浓度是实现最大抗菌效果的前提条件，因此对抗生素浓度进行了控制。测定了113例上颌窦炎患者上颌窦分泌物和/或黏膜中的抗生素浓度，这些患者接受了单剂量或重复剂量的青霉素或四环素治疗，或两种抗生素联合治疗。在30例接受青霉素或四环素治疗的患者中，治疗前后鼻窦分泌物中的细菌生长得到了控制。已证实，普通临床剂量的青霉素和四环素虽然并非总是如此，但可能会使鼻窦分泌物和鼻窦黏膜中的抗生素浓度达到可视为足以治疗的水平，即青霉素大于或等于0.25微克/毫升，四环素大于或等于1.0微克/毫升。这证明了在上颌窦分泌物和鼻窦黏膜中达到足够的抗生素浓度以确保治疗成功的必要性。因此，当分泌物中青霉素或四环素的浓度被认为不足以治疗时，大多数上颌窦分泌物中的细菌生长仍然存在。相比之下，在大多数浓度被认为足够的情况下，细菌被消灭了。
