Gschnait I
Laryngol Rhinol Otol (Stuttg). 1977 Sep;56(9):756-9.
The present study was performed in order to pinpoint whether or not the oral penicillin treatment of the acute purulent maxillary sinusitis, which represents a common treatment modality in general practice, is in fact effective. The efficacy of penicillin V was tested in 32 patients under controlled conditions. In 24 out of 32 cases, which have been treated by administration of 4 X 1 tablet of Ospen 1500 per day, the acute signs and symptoms disappeared completely within a period of 7.4 +/- 2.02 days. The values obtained 4-5 hours after administration of 1 tablet of Ospen 1500 were significantly higher than the minimal inhibitory penicillin concentration for the bacteria tested. The plasma and sinus secret pencillin concentration time curves were found to be parallel. This implies similar kinetics of penicillin V in the plasma and the sinus secret. Since the present study shows that after oral administration penicillin is present in the nasal sinus secret in sufficient concentrations, oral penicillin therapy has been proven a necessful treatment of acute purulent maxillary sinusitis.
本研究旨在确定在一般实践中作为常见治疗方式的口服青霉素治疗急性化脓性上颌窦炎是否真的有效。在可控条件下对32例患者测试了青霉素V的疗效。在32例患者中，有24例每天服用4片1500单位的奥司他韦，急性症状和体征在7.4±2.02天内完全消失。服用1片1500单位奥司他韦4至5小时后测得的值显著高于所测试细菌的青霉素最小抑菌浓度。发现血浆和鼻窦分泌物中青霉素浓度-时间曲线是平行的。这意味着青霉素V在血浆和鼻窦分泌物中的动力学相似。由于本研究表明口服给药后青霉素在鼻窦分泌物中有足够的浓度，口服青霉素疗法已被证明是治疗急性化脓性上颌窦炎的必要方法。
