Tuazon C U, Sheagren J N
Ann Intern Med. 1976 May;84(5):543-6. doi: 10.7326/0003-4819-84-5-543.
The development of antibodies to teichoic acid was studied in 56 patients with infections due to Staphylococcus aureus. All 28 patients with endocarditis eventually developed teichoic acid antibodies demonstrable both by counterimmunoelectrophoresis and by gel diffusion; however, 7 patients were negative on admission. Eight of 15 patients with S. aureus bacteremia developed antibodies by counterimmunoelectrophoresis and 6 of the 8 were positive by gel diffusion; 4 of those 6 had evidence of seeding of S. aureus. Three of 5 patients with osteomyelitis and 1 of 8 with localized peripheral abscesses had teichoic acid antibodies. Titers of 1:4 or greater by gel diffusion were present in 18 of 28 patients with endocarditis compared with only 1 of 10 patients with nonendocarditic staphylococcal infections. Thus, the demonstration and quantitation of teichoic acid antibodies is of great clinical value in the early diagnosis of infections due to S. aureus and in assessing the likelihood of deep intra- or perivascular seeding.
对56例金黄色葡萄球菌感染患者体内针对磷壁酸抗体的产生情况进行了研究。所有28例心内膜炎患者最终均产生了可通过对流免疫电泳和凝胶扩散检测到的磷壁酸抗体；然而，7例患者入院时检测结果为阴性。15例金黄色葡萄球菌菌血症患者中有8例通过对流免疫电泳检测出抗体，其中8例中的6例通过凝胶扩散检测呈阳性；这6例中的4例有金黄色葡萄球菌播散的证据。5例骨髓炎患者中有3例以及8例局限性外周脓肿患者中有1例产生了磷壁酸抗体。28例心内膜炎患者中有18例通过凝胶扩散检测出滴度为1:4或更高，相比之下，10例非心内膜炎葡萄球菌感染患者中只有1例检测出该滴度。因此，磷壁酸抗体的检测和定量在金黄色葡萄球菌感染的早期诊断以及评估深部血管内或血管周围播散的可能性方面具有重要的临床价值。
