Shields M B, Campbell D G, Simmons R J, Hutchinson B T
Arch Ophthalmol. 1976 Mar;94(3):406-10. doi: 10.1001/archopht.1976.03910030194004.
Seven cases are reported, believed to be the first in the literature, in which iris nodules are verified in the complete spectrum of essential iris atrophies. This feature appears late in the course of the disease as small yellow nodules that progressively increase in number and gradually become dark brown. The differential diagnosis of multiple iris nodules includes neurofibromatosis, melanomas, inflammatory nodules, and developmental anomalies such as iridocorneal dysgenesis.
本文报告了7例病例，据信是文献中首次报道的在原发性虹膜萎缩全谱中均证实存在虹膜结节的病例。这一特征在疾病过程后期出现，表现为小的黄色结节，数量逐渐增加并逐渐变为深棕色。多个虹膜结节的鉴别诊断包括神经纤维瘤病、黑色素瘤、炎性结节以及发育异常，如虹膜角膜发育不全。
