Foss A J, Pecorella I, Alexander R A, Hungerford J L, Garner A
Department of Ocular Oncology, Moorfields Eye Hospital, London, UK.
Ophthalmology. 1994 May;101(5):919-24. doi: 10.1016/s0161-6420(13)31239-1.
Intraocular smooth muscle tumors have long been a subject of controversy. The advent of immunohistochemistry with antibodies against HMB-45, S-100, smooth muscle actin, desmin, and vimentin has helped greatly in the distinction between smooth muscle tumors and melanocytic lesions.
Twenty-seven archival tissue blocks from patients who had had intraocular leiomyomas or leiomyosarcomas diagnosed were located and fresh sections cut and stained for the above markers. The cases constituted 24 iris lesions and 3 ciliary body lesions.
All 24 iris tumors were reclassified as iris melanocytic lesions. Two of the three ciliary body leiomyomas retained their classification, and the third was reclassified as a spindle B-cell melanoma.
The authors suggest that intraocular leiomyomas are much rarer than previously suggested and that many of the cases previously reported in the literature are open to question.
眼内平滑肌肿瘤长期以来一直是一个有争议的话题。针对HMB - 45、S - 100、平滑肌肌动蛋白、结蛋白和波形蛋白的抗体免疫组化技术的出现，极大地有助于区分平滑肌肿瘤和黑素细胞病变。
找到27个已诊断为眼内平滑肌瘤或平滑肌肉瘤患者的存档组织块，切取新鲜切片并对上述标志物进行染色。这些病例包括24例虹膜病变和3例睫状体病变。
所有24例虹膜肿瘤均重新分类为虹膜黑素细胞病变。3例睫状体平滑肌瘤中有2例维持原分类，第3例重新分类为梭形B细胞黑色素瘤。
作者认为眼内平滑肌瘤比之前认为的要罕见得多，并且文献中之前报道的许多病例都值得怀疑。
