Carandini M, Heeger D J
Center for Neural Science, New York University, New York 10003.
Science. 1994 May 27;264(5163):1333-6. doi: 10.1126/science.8191289.
Recordings from monkey primary visual cortex (V1) were used to test a model for the visually driven responses of simple cells. According to the model, simple cells compute a linear sum of the responses of lateral geniculate nucleus (LGN) neurons. In addition, each simple cell's linear response is divided by the pooled activity of a large number of other simple cells. The cell membrane performs both operations; synaptic currents are summed and then divided by the total membrane conductance. Current and conductance are decoupled (by a complementary arrangement of excitation and inhibition) so that current depends only on the LGN inputs and conductance depends only on the cortical inputs. Closed form expressions were derived for fitting and interpreting physiological data. The model accurately predicted responses to drifting grating stimuli of various contrasts, orientations, and spatiotemporal frequencies.
来自猴子初级视觉皮层（V1）的记录被用于测试一个关于简单细胞视觉驱动反应的模型。根据该模型，简单细胞计算外侧膝状体核（LGN）神经元反应的线性总和。此外，每个简单细胞的线性反应被大量其他简单细胞的汇总活动除。细胞膜执行这两种操作；突触电流被求和，然后除以总膜电导。电流和电导是解耦的（通过兴奋和抑制的互补排列），以便电流仅取决于LGN输入，而电导仅取决于皮层输入。推导了用于拟合和解释生理数据的闭式表达式。该模型准确地预测了对各种对比度、方向和时空频率的漂移光栅刺激的反应。
