[嘌呤霉素、萘啶酸和环己酰亚胺对神经肌肉传递的影响]
[Effect of puromycin, nalidixic acid and cycloheximide on neuromuscular transmission].
作者信息
Raul F, Nesralla-Lobão H, Nery da Matta A H, Chagas C
出版信息
C R Acad Hebd Seances Acad Sci D. 1975 Oct 27;281(17):1247-51.
PMID:819142
Abstract
The action of puromycin, nalidixic acid and cycloheximid on neuromuscular transmission has been assayed using diaphragm-phrenic nerve preparation from rat. The results demonstrate that all antibiotics used, reversibly blodk neuromuscular transmission. Cycloheximid seems to act presynaptically by inhibiting acetylcholine release from nerve terminal. Puromycin and nalidixic acid act as curare-like agents. They seem to compete with acetylcholine for fixation at the cholinergic receptor.
摘要
使用大鼠膈神经 - 膈肌标本测定了嘌呤霉素、萘啶酸和环己酰亚胺对神经肌肉传递的作用。结果表明，所有使用的抗生素均可可逆性阻断神经肌肉传递。环己酰亚胺似乎通过抑制神经末梢乙酰胆碱的释放而在突触前起作用。嘌呤霉素和萘啶酸的作用类似于箭毒样药物。它们似乎与乙酰胆碱竞争结合胆碱能受体。
Zotero 插件