Li Q, Guo F Q, Gu R Q
Agriculture in Future and Space Life Science Laboratory, Shanghai Institute of Plant Physiology, Academia Sinica, China.
Shi Yan Sheng Wu Xue Bao. 1993 Sep;26(3):269-74.
It has been shown that the radiation resistance of some cruciferous plants is related to some natural radiation protection substances in these plants. Sinapine, which has shown radiation protection effects on barley, wheat and mouse, is one of such substances distributed in cruciferous plants. In this paper, the radiation protection effects of sinapine on Drosophila melanogaster in a sex-linked recessive lethal (SLRL) test system were observed. The sinapine solution could be fed to the D. melanogaster (Oregon K). 40 Gy X-irradiation induced SLRL mutation rate of 8.96%. However, if 10 mg/ml sinapine which was found to have no physiological toxicity or harmful effects on its reproductive function, was fed before 40 Gy X-irradiation, the SLRL mutation rate could be reduced to 0.40%, which was within the range of spontaneous SLRL mutation rate of Oregon K Drosophila, i.e. 0-0.4%. The potential of the using of the very strong radiation protection effects of sinapine in anticarcinogenesis was also discussed.
业已表明，一些十字花科植物的抗辐射性与这些植物中的某些天然辐射防护物质有关。对大麦、小麦和小鼠表现出辐射防护作用的芥子碱，就是分布于十字花科植物中的此类物质之一。本文在性连锁隐性致死（SLRL）试验系统中观察了芥子碱对黑腹果蝇的辐射防护作用。芥子碱溶液可投喂给黑腹果蝇（俄勒冈K品系）。40 Gy的X射线照射诱导的SLRL突变率为8.96%。然而，如果在40 Gy的X射线照射前投喂对其生殖功能无生理毒性或有害影响的10 mg/ml芥子碱，SLRL突变率可降至0.40%，该数值处于俄勒冈K品系果蝇自发SLRL突变率范围内，即0 - 0.4%。文中还讨论了芥子碱极强的辐射防护作用在抗癌方面的应用潜力。
