Lauritsen J G, Jøorgensen J, Kissmeyer-Nielsen F
Clin Genet. 1976 Jun;9(6):575-82. doi: 10.1111/j.1399-0004.1976.tb01615.x.
The frequencies of antigen-incompatible matings within the HLA, Rhesus, Lutheran, MN, S. Lewis, Kell, P and Duffy systems were studied in 481 parents of karyotyped spontaneous abortuses. The results were compared with the calculated mating frequencies in control samples consisting of 1,197 (HLA) and 12,123 (the remaining eight systems) individuals, respectively. The only significant difference observed at the 5% level was an increased frequency of matins in which the mother was Lu (a+) and had a karyotypically abnormal abortus. It is concluded that antigen incompatibility between the parents within the nine systems studied is not important in the aetiology of early spontaneous abortion or causative in the origin of chromosome anomalies in the foetus.
在481例核型分析为自然流产儿的父母中，研究了HLA、恒河猴、路德、MN、S. 刘易斯、凯尔、P和达菲系统内抗原不相容交配的频率。将结果分别与由1197例个体（HLA）和12123例个体（其余八个系统）组成的对照样本中计算出的交配频率进行比较。在5%的水平上观察到的唯一显著差异是，母亲为Lu（a+）且有核型异常流产儿的交配频率增加。得出的结论是，在所研究的九个系统中，父母之间的抗原不相容在早期自然流产的病因学中并不重要，也不是胎儿染色体异常起源的原因。
