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以大鼠肠道过敏反应作为食物过敏模型

Intestinal anaphylaxis in the rat as a model of food allergy.

作者信息

Byars N E, Ferraresi R W

出版信息

Clin Exp Immunol. 1976 May;24(2):352-6.

PMID:819192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538410/
Abstract

An animal model of food allergy has been developed in which some aspects of the allergic response could be quantified and the effects of various drugs evaluated. The change in permeability of the intestinal tract of actively sensitized rats, after oral challenge with the sensitizing antigen, was the parameter measured. Rats were sensitized by injection of egg albumin and B. pertussis vaccine to induce reaginic antibody to egg albumin. Two weeks after sensitization, 125I-labelled bovine serum albumin (125I-labelled BSA) was injected intravenously, followed by oral challenge with egg albumin. Pieces of intestinal tissue were obtained and the amount of 125I-labelled BSA determined in a gamma counter. The amount of 125I-labelled BSA in the intestinal tissue of sensitized and challenged rats regularly showed an increase of greater than 100% above values for control rats.

摘要

已经建立了一种食物过敏动物模型，在该模型中可以对过敏反应的某些方面进行量化，并评估各种药物的效果。测量的参数是用致敏抗原进行口服激发后，主动致敏大鼠肠道的通透性变化。通过注射卵白蛋白和百日咳疫苗使大鼠致敏，以诱导产生针对卵白蛋白的反应素抗体。致敏两周后，静脉注射125I标记的牛血清白蛋白（125I标记的BSA），随后用卵白蛋白进行口服激发。获取肠道组织切片，并在γ计数器中测定125I标记的BSA的量。致敏并激发的大鼠肠道组织中125I标记的BSA的量通常比对照大鼠的值增加超过100%。

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本文引用的文献

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Effect of disodium cromoglycate on asthmatic reactions to alcoholic beverages.色甘酸钠对酒精饮料所致哮喘反应的影响。
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