Arimura A, Schally A V
Endocrinology. 1976 Apr;98(4):1069-72. doi: 10.1210/endo-98-4-1069.
Passive immunization of rats with an antiserum to synthetic somatostatin caused a 250% elevation of basal serum TSH levels and a nearly 200% increase in TSH-response to TRH. These findings strongly support the concept that pituitary thyrotrophs are regulated by endogenous somatostatin as well as by TRH and thyroid hormones. Serum GH levels in the antiserum-treated rats were considerably higher than those in rats which received normal serum. No clearcut influence on prolactin secretion was observed.
用抗合成生长抑素抗血清对大鼠进行被动免疫，导致基础血清促甲状腺激素（TSH）水平升高250%，TSH对促甲状腺激素释放激素（TRH）的反应增加近200%。这些发现有力地支持了垂体促甲状腺细胞受内源性生长抑素以及TRH和甲状腺激素调节的概念。抗血清处理的大鼠血清生长激素（GH）水平明显高于接受正常血清的大鼠。未观察到对催乳素分泌有明确影响。
