Lugo de Yarbuh A, Añez N, Petit de Peña Y, Burguera J L, Burguera M
Departamento de Biologia, Facultad de Ciencias, Universidad de Los Andes, Merida, Venezuela.
Ann Trop Med Parasitol. 1994 Feb;88(1):37-41. doi: 10.1080/00034983.1994.11812832.
Hamsters were experimentally infected with Leishmania garnhami and then treated for 10 days with N-methyl-glucamine antimoniate (Glucantime); 60 mg/kg/day by intramuscular (im) or intralesional (il) routes. Hydride generation-atomic absorption spectroscopy was used to determine the concentrations of SbIII and SbV in the blood serum and total Sb in the tissues of the hamsters from 1 to 30 days after initiation of the treatment. Serum concentrations of SbIII and SbV were always similar. Total Sb concentrations were significantly higher in the relatively parasite-rich spleen and lesion than in any other tissue, whether treatment had been given im or il. Reduction of SbV to SbIII is probably associated with decreasing size and healing of the leishmanial ulcers. Tissue Sb kinetics is related to Leishmania behaviour and attention is drawn to the use of antimonial pentavalent compounds for diseases, other than leishmaniasis, that can affect the heart, liver and/or spleen, such as Chagas disease.
将仓鼠用杜氏利什曼原虫进行实验性感染，然后用葡甲胺锑酸盐（葡糖胺锑）治疗10天；通过肌肉注射（im）或病灶内注射（il）途径给药，剂量为60毫克/千克/天。采用氢化物发生-原子吸收光谱法测定治疗开始后1至30天仓鼠血清中SbIII和SbV的浓度以及组织中总锑的含量。血清中SbIII和SbV的浓度始终相似。无论采用肌肉注射还是病灶内注射治疗，相对富含寄生虫的脾脏和病灶处的总锑浓度均显著高于其他任何组织。SbV还原为SbIII可能与利什曼溃疡的尺寸减小和愈合有关。组织锑动力学与利什曼原虫的行为有关，并提请注意五价锑化合物在治疗除利什曼病之外的、可影响心脏、肝脏和/或脾脏的疾病（如恰加斯病）中的应用。
