Mumby D G, Pinel J P
Department of Psychology, University of British Columbia, Vancouver, Canada.
Behav Neurosci. 1994 Feb;108(1):11-8. doi: 10.1037//0735-7044.108.1.11.
Rats with bilateral lesions of lateral entorhinal cortex and perirhinal cortex were tested on a nonrecurring-items delayed nonmatching-to-sample (DNMS) task resembling the one that is commonly used to study object recognition in monkeys. The rats were tested at retention delays of 4 s, 15 s, 60 s, 120 s, and 600 s before and after surgery. After surgery, they displayed a delay-dependent deficit: They performed normally at the 4-s delay but were impaired at delays of 15 s or longer. The addition of bilateral amygdala lesions did not increase their DNMS deficits. The present finding of a severe DNMS deficit following rhinal cortex damage is consistent with the authors' previous finding that bilateral lesions of the hippocampus and amygdala cause only mild DNMS deficits in rats unless there is also damage to rhinal cortex (D.G. Mumby, E.R. Wood, & J.P.J. Pinel, 1992). These findings add to accumulating evidence that the rhinal cortex, but not the amygdala, plays a critical role in object recognition.
对双侧内嗅皮层和嗅周皮层受损的大鼠进行了一项非重复项目延迟非匹配样本（DNMS）任务测试，该任务类似于常用于研究猴子物体识别的任务。在手术前后，对大鼠分别进行了4秒、15秒、60秒、120秒和600秒的延迟记忆测试。手术后，它们表现出延迟依赖性缺陷：在4秒延迟时表现正常，但在15秒或更长时间延迟时受损。双侧杏仁核损伤并未增加它们的DNMS缺陷。目前关于嗅皮层损伤后严重DNMS缺陷的发现与作者之前的发现一致，即除非嗅皮层也受损，否则海马体和杏仁核的双侧损伤只会导致大鼠出现轻微的DNMS缺陷（D.G. 芒比、E.R. 伍德和J.P.J. 皮内尔，1992年）。这些发现进一步证明了嗅皮层而非杏仁核在物体识别中起关键作用。
