Stuckey M, Quinn P A, Gelfand E W
Lancet. 1978 Oct 28;2(8096):917-20. doi: 10.1016/s0140-6736(78)91632-x.
A 10-year-old boy with confirmed congenital agammaglobulinaemia presented with polyarthritis while on gammaglobulin replacement therapy. Initial cultures of material aspirated from an abscess and of joint fluid were negative, and symptoms progressed despite antibiotic therapy. Synovial-biopsy material, cultured specifically for mycoplasmas, was positive for Ureaplasma urealyticum as were the blood, abscess fluids, throat-swab, and nasopharyngeal secretions. Therapy, based on in-vitro studies of antibiotic susceptibilities of the organism, resulted in the eradication of the infection and resolution of the arthritis. These findings suggest that U. urealyticum may be capable of inducing polyarthritis in man.
一名确诊为先天性无丙种球蛋白血症的10岁男孩在接受丙种球蛋白替代治疗时出现多关节炎。最初从脓肿抽取的物质和关节液培养结果为阴性，尽管使用了抗生素治疗，症状仍在进展。专门培养支原体的滑膜活检材料检测出解脲脲原体呈阳性，血液、脓肿液、咽拭子和鼻咽分泌物检测结果也一样。基于对该生物体抗生素敏感性的体外研究进行的治疗，成功根除了感染，关节炎症状也得以缓解。这些发现表明，解脲脲原体可能能够在人类中诱发多关节炎。
