Young J L, Hillbrand M
Whiting Forensic Institute, Middletown, Connecticut 06457.
Bull Am Acad Psychiatry Law. 1994;22(1):53-61.
A small but growing number of reports document the antiaggressive effect of carbamazepine. Although it is supported by a small total number of patients studied with less than ideal rigor, the use of this medication as a means of reducing aggressive behavior is becoming an established clinical practice. The target diagnostic spectrum is broad, and the effect appears within days when it occurs. To promote both wider practice and further study, the authors summarize and briefly evaluate the reported investigations, single case studies, and articles related to the efficacy of carbamazepine for reducing aggression. Conceptual problems in aggression research, the relationships between epilepsy and aggression, possible mechanisms of action for this effect of carbamazepine, and practical clinical considerations are outlined.
越来越多的报告记录了卡马西平的抗攻击作用，尽管研究的患者总数较少且严谨性欠佳，但将这种药物作为减少攻击行为的手段已成为一种既定的临床实践。其目标诊断范围广泛，且一旦起效，数天内即可显现效果。为了促进更广泛的应用和进一步的研究，作者总结并简要评估了已报道的有关卡马西平减少攻击行为疗效的调查、单病例研究及文章。概述了攻击行为研究中的概念性问题、癫痫与攻击行为之间的关系、卡马西平产生这种作用的可能机制以及实际临床考量。
