Drake M E, Weate S J, Newell S A, Padamadan H, Pakalnis A
Clinical Neurophysiology Laboratory, Ohio State University Hospital, Columbus.
Clin Electroencephalogr. 1994 Apr;25(2):59-62. doi: 10.1177/155005949402500206.
Seizure patients often complain of sleepiness or disturbed sleep. Although susceptible of medication effect, the multiple sleep latency test (MSLT) may quantify daytime sleepiness and help to establish whether qualitative sleep disturbance accompanies epilepsy. In order to measure daytime sleepiness in epilepsy patients, 30 patients with newly diagnosed or presently untreated complex partial seizures had MSLT after an overnight sleep EEG that showed no sleep deprivation or nocturnal seizures. Four 20-minute naps were undertaken at 09:00, 11:00, 13:00, and 15:00, and sleep latency was recorded along with 8 channels of EEG. Twenty of 30 seizure patients reported subjective sleepiness. Eight patients had average sleep latencies less than 8 minutes, and 3 had latencies less than 5 minutes. No sleep onset REM or respiratory disturbance was noted. Twenty-five patients had EEG abnormalities but none had ictal seizures. Right temporal epileptiform activity correlated with sleepiness. MSLT may quantify sleepiness in epilepsy patients, which is common but may be subjective or psychophysiological. Some patients with partial seizures have persistent daytime sleepiness independent of medication, possibly related to residual medication effects or non-specific effect of their epileptogenic foci.
癫痫患者常常抱怨困倦或睡眠障碍。尽管易受药物影响，但多次睡眠潜伏期试验（MSLT）可量化日间嗜睡程度，并有助于确定癫痫是否伴有质性睡眠障碍。为了测量癫痫患者的日间嗜睡情况，30例新诊断或目前未接受治疗的复杂部分性发作患者在进行整夜睡眠脑电图检查显示无睡眠剥夺或夜间癫痫发作后接受了MSLT。在09:00、11:00、13:00和15:00进行了四次20分钟的小睡，并记录睡眠潜伏期以及8通道脑电图。30例癫痫患者中有20例报告有主观嗜睡。8例患者的平均睡眠潜伏期小于8分钟，3例患者的潜伏期小于5分钟。未观察到睡眠始发快速眼动或呼吸障碍。25例患者脑电图异常，但均无发作期癫痫发作。右侧颞叶癫痫样活动与嗜睡相关。MSLT可量化癫痫患者的嗜睡程度，嗜睡在癫痫患者中很常见，但可能是主观的或心理生理的。一些部分性发作患者存在与药物无关的持续性日间嗜睡，可能与残留药物作用或致痫灶的非特异性效应有关。
