Orr W C, Shamma-Othman Z, Levin D, Othman J, Rundell O H
Presbyterian Hospital, Oklahoma City.
Chest. 1990 Mar;97(3):583-5. doi: 10.1378/chest.97.3.583.
Fourteen patients with chronic obstructive pulmonary disease (COPD) and chronic hypoxemia were studied to evaluate the relationship between hypoxemia and objective and subjective daytime sleepiness. Patients were selected with a waking PaO2 of less than 70 mm Hg and less than 50 percent predicted FEV1. Clinically, none of these patients had complaints of significant daytime sleepiness. Each patient underwent standard all-night polysomnographic evaluation followed by a multiple sleep latency test (MSLT). There was no significant correlation between the mean sleep onset latency for the MSLT and the waking PaO2, PCO2, FEV1, or spontaneous desaturations during sleep. Patients with COPD exhibited a mean MSLT that was within normal limits, despite a short total sleep time and numerous arousals from sleep. We conclude that there appears to be no relationship between chronic daytime hypoxemia and subjective reports and objective measures of daytime sleepiness.
对14例慢性阻塞性肺疾病（COPD）合并慢性低氧血症患者进行了研究，以评估低氧血症与客观及主观日间嗜睡之间的关系。入选患者清醒时的动脉血氧分压（PaO2）低于70 mmHg，且第一秒用力呼气容积（FEV1）低于预测值的50%。临床上，这些患者均无明显的日间嗜睡主诉。每位患者均接受了标准的整夜多导睡眠图评估，随后进行多次睡眠潜伏期试验（MSLT）。MSLT的平均睡眠开始潜伏期与清醒时的PaO2、二氧化碳分压（PCO2）、FEV1或睡眠期间的自发血氧饱和度下降之间无显著相关性。尽管总睡眠时间较短且睡眠中觉醒频繁，但COPD患者的MSLT平均值仍在正常范围内。我们得出结论，慢性日间低氧血症与主观报告及日间嗜睡的客观测量之间似乎没有关系。
