Calcium-dependent stimulation of erythrocyte membrane phospholipid fatty acid incorporation by the ionophore A23187.

Treatment of human erythrocytes with A23187, a divalent cation ionophore, results in a calcium-dependent increase in the rate of incorporation of palmitic, oleic, and linoleic acids into phosphatidylethanolamine. Incorporation of fatty acids into phosphatidylcholine is unaffected by A23187. This calcium-dependent stimulation of membrane phosphatidylethanolamine fatty acid turnover by A23187 may be related to the changes in erythrocyte membrane function induced by A23187 that have been observed previously.