[Clinical and pathological studies of malignant fibrous histiocytoma (MFH) in the oral and maxillofacial regions with report of 15 cases].

This paper reports 5 patients with MFH in the soft tissues and 10 in the jaws. Fourteen patients (5 in soft tissues and 9 in jaws) underwent surgery, 5 and 3 of the 9 bone cases received additional irradiation and chemotherapy respectively. Fourteen patients had been followed up for 6 months to 4 and 1/2 years. Two patients of jaw had local recurrences 1 to 8 months following surgery; 6 of 9 ones with follow-up died, 2 of whom were associated with pulmonary metastases. MFH of bone showed significantly worse prognosis than those localized in soft tissues, particularly in maxilla. Pathologically, the tumors of this series were divided into 5 types. The relation between the mitosis and the malignancy of MFH in the jaws was significant. Immunohistochemical stains for lysozyme, A, AT and ACT showed that ACT was the most sensitive marker for MFH.