Levi F, Randimbison L, Te V C, La Vecchia C
Registre vaudois des tumeurs, Institut universitaire de médecine sociale et préventive, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Int J Cancer. 1994 Jun 1;57(5):681-3. doi: 10.1002/ijc.2910570512.
There is a general agreement that fibroadenoma is associated with a certain increase in breast cancer risk, but the risk estimates appear heterogeneous according to various studies. To provide further quantitative and population-based estimates of breast cancer risk in women with histologically confirmed fibroadenomas, we linked data of 1,461 incident cases of fibroadenoma (median age, 37 years) to the Cancer Registry of the Swiss Canton of Vaud (about 600,000 inhabitants) over the period 1977-1991. After exclusion of 57 synchronous breast neoplasms, a total of 17 cases of breast cancer were observed vs. 10.9 expected (standardised incidence ratio, SIR, 1.6; 90% confidence interval: 1.1-2.1). The SIR was similar in the short term (3-5 years) and in the medium-long term (> 5 years) following diagnosis of fibroadenoma. The cumulative risk of invasive breast cancer was 0.7% after 5 years and 2.2% after 12 years following diagnosis of fibroadenoma. This is not negligible on account of the young age of our cohort.
人们普遍认为纤维腺瘤与乳腺癌风险的一定程度增加相关，但根据各种研究，风险估计似乎存在异质性。为了进一步提供基于人群的组织学确诊纤维腺瘤女性乳腺癌风险的定量估计，我们将1977年至1991年期间瑞士沃州癌症登记处（约60万居民）的1461例纤维腺瘤发病病例（中位年龄37岁）的数据进行了关联。排除57例同步性乳腺肿瘤后，共观察到17例乳腺癌，而预期为10.9例（标准化发病比，SIR，1.6；90%置信区间：1.1 - 2.1）。纤维腺瘤诊断后的短期（3 - 5年）和中长期（>5年）SIR相似。纤维腺瘤诊断后5年浸润性乳腺癌的累积风险为0.7%，12年后为2.2%。鉴于我们队列中患者的年轻年龄，这一风险不可忽视。
