Severien C, Lehners T H
Universitätskinderklinik, St. Josef-Hospital Bochum.
Klin Padiatr. 1994 Mar-Apr;206(2):108-11. doi: 10.1055/s-2008-1046592.
This study was done to analyze the epidemiology of invasive Haemophilus influenzae disease in Bochum city area. Forty-eight children with invasive Haemophilus influenzae infections were treated at the University Children's Hospital in Bochum during the study period from January 1971 to June 1992. Clinical manifestations included meningitis (n = 34), epiglottitis (n = 8), pneumonia (n = 2), bacteremia (n = 2), cellulitis (n = 1) and osteomyelitis (n = 1). The overall yearly incidence rate for all invasive Haemophilus influenzae infections was 13 per 100,000 children younger than five years of age, with a marked increase in the last six years. Haemophilus influenzae meningitis showed no significant change during the study period with an overall yearly incidence of 9 per 100,000 children younger than five years. Twenty-eight cases (58%) of all invasive Haemophilus influenzae infections occurred in patients under two years of age and five cases (10%) were younger than six months. Invasive Haemophilus influenzae disease showed no seasonal prevalence. All isolates were susceptible to ampicillin. No deaths occurred, but severe bilateral deafness resulted in one patient with meningitis. Prospective epidemiologic studies are needed to estimate clinical efficacy of the Haemophilus influenzae type b immunization program in Germany.
本研究旨在分析波鸿市地区侵袭性流感嗜血杆菌疾病的流行病学情况。在1971年1月至1992年6月的研究期间，波鸿大学儿童医院收治了48例侵袭性流感嗜血杆菌感染患儿。临床表现包括脑膜炎（n = 34）、会厌炎（n = 8）、肺炎（n = 2）、菌血症（n = 2）、蜂窝织炎（n = 1）和骨髓炎（n = 1）。所有侵袭性流感嗜血杆菌感染的总体年发病率为每10万名5岁以下儿童中有13例，且在过去六年中有显著上升。流感嗜血杆菌脑膜炎在研究期间无显著变化，5岁以下儿童的总体年发病率为每10万名中有9例。所有侵袭性流感嗜血杆菌感染病例中，28例（58%）发生在2岁以下患者，5例（10%）年龄小于6个月。侵袭性流感嗜血杆菌疾病无季节性流行。所有分离株对氨苄西林敏感。无死亡病例，但有1例脑膜炎患者导致严重双侧耳聋。需要进行前瞻性流行病学研究以评估德国b型流感嗜血杆菌免疫规划的临床效果。
