Sosa-Iglesias E G, González-Mancilla S, Juárez-Ahuactzi E, López-Merino A, Corona-Reyes D
Centro de Investigaciones en Ciencias Microbiológicas, Benemérita Universidad Autónoma de Puebla, Mexico.
Rev Latinoam Microbiol. 1995 Jul-Sep;37(3):189-99.
Haemophilus influenzae has been recognized as one of the most important pathogen in the pediatric population younger than 5 years old. We analized some characteristics of the infectious diseases by Haemophilus influenzae in the pediatric group from 1985 to 1990 in two hospitals of Puebla city. From 321 children studies cases included for this work, fifty of those had infectious diseases by H. influenzae. Forty six percent of the patients developed meningitis, 22% otitis media, 12% sepsis, 10% pneumonia and 10% other infectious diseases. The majority of cases occurred in males but the difference was not statistically significant (p > 0.05). Eighty percent of diseases by H. influenzae occurred in infants younger than 24 months. The serovar b was the most frequent in invasive infections and nontypable strains were frequent in otitis media. The biovars I and IV were isolated from invasive infections. During this study two children died with meningitis and 3 patients had severe neurological damage. This finding suggests that is necessary to vaccine this population to prevent the morbilethality of infectious diseases by Haemophilus influenzae.
流感嗜血杆菌已被公认为是5岁以下儿童群体中最重要的病原体之一。我们分析了普埃布拉市两家医院1985年至1990年儿科组中流感嗜血杆菌所致传染病的一些特征。在这项研究纳入的321例儿童病例中，有50例患有流感嗜血杆菌所致传染病。46%的患者发生脑膜炎，22%发生中耳炎，12%发生败血症，10%发生肺炎，10%发生其他传染病。大多数病例发生在男性，但差异无统计学意义（p>0.05）。80%的流感嗜血杆菌所致疾病发生在24个月以下的婴儿。b型血清型在侵袭性感染中最常见，不可分型菌株在中耳炎中常见。生物变种I和IV从侵袭性感染中分离出来。在这项研究期间，两名儿童死于脑膜炎，3名患者有严重的神经损伤。这一发现表明，有必要对该人群进行疫苗接种，以预防流感嗜血杆菌所致传染病的病死率。
