衰老与酶的改变：综述
Aging and the alteration of enzymes: a review.
作者信息
Rothstein M
出版信息
Mech Ageing Dev. 1975 Sep-Dec;4(5-6):325-38. doi: 10.1016/0047-6374(75)90033-0.
PMID:819726
Abstract
The present status of research on age-related alterations of enzymes is reviewed. Evidence which makes it clear that "altered" enzymes do, in fact, exist in old animals is presented. The alteration may result from either a sequence change or a post-synthetic modification. The "error hypothesis" would support the former mechanism; a proposal based upon increasing half-lives of proteins with age could explain the latter. Evidence supporting or contradicting these alternatives is discussed.
摘要
本文综述了与年龄相关的酶变化的研究现状。文中列举了证据，明确表明老龄动物体内确实存在“改变的”酶。这种改变可能是由序列变化或合成后修饰引起的。“错误假说”支持前一种机制；基于蛋白质半衰期随年龄增长而延长的观点可以解释后一种机制。文中还讨论了支持或反驳这些观点的证据。
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