France C, Adler P S, France J, Ditto B
Department of Psychology, Ohio University, Athens 45701.
Psychosom Med. 1994 Jan-Feb;56(1):52-60. doi: 10.1097/00006842-199401000-00007.
Parental history of hypertension was associated with significantly lower venipuncture pain ratings in women with little or no blood donation experience. Healthy men (N = 288) and women (N = 434) presenting at Red Cross blood donor clinics provided pain ratings in response to an initial blood sample and venipuncture for blood donation. Analyses were restricted to 460 individuals with and without a confirmed parental history of hypertension (N = 188 and 272, respectively). There were no significant gender or parental history effects on initial blood sample pain ratings. Significantly lower venipuncture pain ratings were observed 1) for men vs. women, 2) for more experienced blood donors, and 3) among subjects with 0-1 previous donations, for women with vs. women without a parental history of hypertension. Although pain ratings were positively correlated with subjective anxiety throughout donation, there were no significant differences in anxiety ratings between women with and without a parental history of hypertension. The results provide suggestive evidence of an association between genetic risk for hypertension and decreased pain sensitivity.
在献血经验很少或没有献血经验的女性中，父母有高血压病史与静脉穿刺疼痛评分显著降低有关。在红十字会献血诊所前来献血的健康男性（N = 288）和女性（N = 434）对首次采血和献血静脉穿刺的疼痛进行了评分。分析仅限于460名有或没有经证实的父母高血压病史的个体（分别为N = 188和272）。在首次采血疼痛评分上，没有显著的性别或父母病史影响。观察到静脉穿刺疼痛评分显著降低的情况如下：1）男性与女性相比；2）献血经验较多的献血者；3）在之前献血0 - 1次的受试者中，有父母高血压病史的女性与无父母高血压病史的女性相比。尽管在整个献血过程中疼痛评分与主观焦虑呈正相关，但有父母高血压病史的女性和无父母高血压病史的女性在焦虑评分上没有显著差异。结果提供了提示性证据，表明高血压的遗传风险与疼痛敏感性降低之间存在关联。
