未选择人群中的结肠息肉：患病率、特征及关联
Colonic polyps in an unselected population: prevalence, characteristics, and associations.
作者信息
Cannon-Albright L A, Bishop D T, Samowitz W, DiSario J A, Lee R, Burt R W
机构信息
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City.
出版信息
Am J Gastroenterol. 1994 Jun;89(6):827-31.
OBJECTIVES
To provide a proctosigmoidoscopic review of a very large set of unselected control subjects, providing an unbiased view of colonic polyps in the general population.
METHODS
Sigmoidoscopic data from 406 sequentially recruited subjects were analyzed. Participation rates were over 85%, and subjects were thus free of the usual selection bias.
RESULTS
Thirty-eight percent of screened individuals were found to have distal colonic polyps. Adenomas were found in 12%, and hyperplastic polyps were found in 30% of screened individuals. Adenomas were more prevalent in males and in older individuals. Hyperplastic prevalence did not differ significantly by gender or age. Synchronous adenomatous and hyperplastic polyps occurred in 3% of screened individuals, but these lesions were not associated.
CONCLUSIONS
Distal colonic adenomatous and hyperplastic polyps are very common in the general population and are not associated. The high frequency of these polyps raises questions about the feasibility of biopsy for all polyps, and suggests that further study is needed to determine the appropriate indications for subsequent colonoscopy.
目的
对大量未经挑选的对照受试者进行直肠乙状结肠镜检查，以提供普通人群中结肠息肉的无偏视图。
方法
分析了406名依次招募的受试者的乙状结肠镜检查数据。参与率超过85%，因此受试者没有常见的选择偏倚。
结果
38%的筛查个体被发现有远端结肠息肉。12%的个体发现有腺瘤，30%的筛查个体发现有增生性息肉。腺瘤在男性和老年人中更常见。增生性息肉的患病率在性别或年龄上没有显著差异。3%的筛查个体出现了同步腺瘤性息肉和增生性息肉，但这些病变并无关联。
结论
远端结肠腺瘤性息肉和增生性息肉在普通人群中非常常见且无关联。这些息肉的高发生率引发了对所有息肉进行活检可行性的质疑，并表明需要进一步研究以确定后续结肠镜检查的合适指征。
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