仙台病毒的一株野外分离株：其对小鼠的高毒力及与原型株的遗传差异。
A field isolate of Sendai virus: its high virulence to mice and genetic divergence form prototype strains.
作者信息
Sakaguchi T, Kiyotani K, Sakaki M, Fujii Y, Yoshida T
机构信息
Department of Bacteriology, Hiroshima University School of Medicine, Japan.
出版信息
Arch Virol. 1994;135(1-2):159-64. doi: 10.1007/BF01309773.
PMID:8198441
Abstract
A field isolate of Sendai virus, the Hamamatsu strain, was far more virulent in mice than the prototype Z strain. The Hamamatsu strain replicated more efficiently in the mouse lung than the Z strain, causing deteriorating lung lesions. Nucleotide sequence analysis of the HN, F and M genes revealed that the Hamamatsu strain was divergent from the prototype Z, Harris and Fushimi strains.
摘要
仙台病毒的一株野毒株，即滨松株，在小鼠中的毒性比原型Z株强得多。滨松株在小鼠肺中的复制效率高于Z株，导致肺部病变恶化。对HN、F和M基因的核苷酸序列分析表明，滨松株与原型Z株、哈里斯株和伏见株不同。
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