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仙台病毒的一株野外分离株：其对小鼠的高毒力及与原型株的遗传差异。

A field isolate of Sendai virus: its high virulence to mice and genetic divergence form prototype strains.

作者信息

Sakaguchi T, Kiyotani K, Sakaki M, Fujii Y, Yoshida T

机构信息

Department of Bacteriology, Hiroshima University School of Medicine, Japan.

出版信息

Arch Virol. 1994;135(1-2):159-64. doi: 10.1007/BF01309773.

DOI:10.1007/BF01309773
PMID:8198441
Abstract

A field isolate of Sendai virus, the Hamamatsu strain, was far more virulent in mice than the prototype Z strain. The Hamamatsu strain replicated more efficiently in the mouse lung than the Z strain, causing deteriorating lung lesions. Nucleotide sequence analysis of the HN, F and M genes revealed that the Hamamatsu strain was divergent from the prototype Z, Harris and Fushimi strains.

摘要

仙台病毒的一株野毒株，即滨松株，在小鼠中的毒性比原型Z株强得多。滨松株在小鼠肺中的复制效率高于Z株，导致肺部病变恶化。对HN、F和M基因的核苷酸序列分析表明，滨松株与原型Z株、哈里斯株和伏见株不同。

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A field isolate of Sendai virus: its high virulence to mice and genetic divergence form prototype strains.仙台病毒的一株野外分离株：其对小鼠的高毒力及与原型株的遗传差异。
Arch Virol. 1994;135(1-2):159-64. doi: 10.1007/BF01309773.
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本文引用的文献

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Newborn virus pneumonitis (type Sendai). II. The isolation of a new virus possessing hemagglutinin activity.新生儿病毒性肺炎（仙台型）。II. 一种具有血凝素活性的新病毒的分离。
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Sequence of 3,687 nucleotides from the 3' end of Sendai virus genome RNA and the predicted amino acid sequences of viral NP, P and C proteins.来自仙台病毒基因组RNA 3'端的3687个核苷酸序列以及病毒核蛋白（NP）、磷蛋白（P）和C蛋白的预测氨基酸序列。
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仙台病毒以多方面的方式靶向炎症反应以及干扰素诱导的抗病毒状态。
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Identification of mutations associated with attenuation of virulence of a field Sendai virus isolate by egg passage.通过鸡胚传代鉴定与一株仙台病毒野毒株毒力减弱相关的突变
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Involvement of the leader sequence in Sendai virus pathogenesis revealed by recovery of a pathogenic field isolate from cDNA.从cDNA中拯救出致病性野毒株揭示了仙台病毒致病机制中前导序列的作用。
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仙台病毒在小鼠肺中与蛋白酶介导的激活相关的亲肺性
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Nucleotide sequence of a Sendai virus genome region covering the entire M gene and the 3' proximal 1013 nucleotides of the F gene.仙台病毒基因组区域的核苷酸序列，该区域涵盖整个M基因以及F基因3'端近端1013个核苷酸。
Nucleic Acids Res. 1984 Nov 12;12(21):7965-73. doi: 10.1093/nar/12.21.7965.
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Analysis of the Sendai virus M gene and protein.仙台病毒M基因与蛋白分析
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6
Determination of the complete nucleotide sequence of the Sendai virus genome RNA and the predicted amino acid sequences of the F, HN and L proteins.仙台病毒基因组RNA完整核苷酸序列及F、HN和L蛋白预测氨基酸序列的测定。
Nucleic Acids Res. 1986 Feb 25;14(4):1545-63. doi: 10.1093/nar/14.4.1545.
7
Sequence determination of the Sendai virus HN gene and its comparison to the influenza virus glycoproteins.仙台病毒HN基因的序列测定及其与流感病毒糖蛋白的比较。
Cell. 1985 May;41(1):269-78. doi: 10.1016/0092-8674(85)90080-7.
8
Sequence determination of the Sendai virus fusion protein gene.仙台病毒融合蛋白基因的序列测定
J Gen Virol. 1985 Feb;66 ( Pt 2):317-31. doi: 10.1099/0022-1317-66-2-317.
9
Pneumopathogenicity in mice of a Sendai virus mutant, TSrev-58, is accompanied by in vitro activation with trypsin.仙台病毒突变体TSrev-58对小鼠的肺致病性与胰蛋白酶在体外的激活作用有关。
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10
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Microbiol Immunol. 1988;32(2):235-40. doi: 10.1111/j.1348-0421.1988.tb01383.x.