Yamaguchi R, Iwai H, Ueda K
Department of Veterinary Public Health, Institute of Public Health, Tokyo.
Microbiol Immunol. 1988;32(2):235-40. doi: 10.1111/j.1348-0421.1988.tb01383.x.
The virulence of five Sendai virus strains (MN, Z, KN, Mol, and Hm) isolated from laboratory rodents was compared, using 3-week-old female Jcl-ICR mice. The virulence of the strains was Mol, MN, KN, Z, and Hm in decreasing order. The 50% lethal dose and 50% lung consolidation inducing dose of the highest virulent strain differed by the order of more than 10(3) and 10(6), respectively, from those of the lowest virulent one. Other properties such as the growth rate in LLC-MK2 cells, neuraminidase activities, and molecular weights of structural proteins also differed among the virus strains. These results indicate that Sendai virus prevailing in laboratory rodents is not homogenous with respect to virulence and some other properties.
使用3周龄雌性Jcl-ICR小鼠比较了从实验啮齿动物中分离出的5株仙台病毒（MN、Z、KN、Mol和Hm）的毒力。毒株的毒力由高到低依次为Mol、MN、KN、Z和Hm。毒力最强的毒株的50%致死剂量和50%致肺实变剂量与毒力最弱的毒株相比，分别相差超过10³和10⁶倍。病毒毒株在LLC-MK2细胞中的生长速率、神经氨酸酶活性以及结构蛋白的分子量等其他特性也有所不同。这些结果表明，在实验啮齿动物中流行的仙台病毒在毒力和其他一些特性方面并非同质。
