形态学上表现为大颗粒淋巴细胞白血病的成人T细胞白血病/淋巴瘤。

Adult T-cell leukaemia/lymphoma featuring a large granular lymphocyte leukaemia morphologically.

作者信息

Sakamoto Y, Kawachi Y, Uchida T, Abe T, Mori M, Setsu K, Indo N

机构信息

Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan.

出版信息

Br J Haematol. 1994 Feb;86(2):383-5. doi: 10.1111/j.1365-2141.1994.tb04745.x.

DOI:10.1111/j.1365-2141.1994.tb04745.x

PMID:8199030

Abstract

A 70-year-old man from an endemic area of human T-cell lymphotropic virus type I (HTLV-I) developed rapid generalized lymphadenopathy and abdominal tumours. The white blood cell count was 198.3 x 10(9)/l with 93% lymphocytes, 66.3% of which expressed large granular lymphocytes (LGLs). Bone marrow and lymph nodes were also infiltrated by LGLs. Surface markers were positive for CD4, CD25 and HLA-DR, and negative for CD3, CD8, CD16, CD56 and CD57. A monoclonal integration of HTLV-I proviral DNA was demonstrated on these LGLs by Southern blot hybridization analysis. This fact indicates that some adult T-cell leukaemia/lymphoma may morphologically present LGL leukaemia.

摘要

一名来自人类T细胞白血病病毒I型（HTLV-I）流行地区的70岁男性出现了快速进展的全身淋巴结肿大和腹部肿瘤。白细胞计数为198.3×10⁹/L，淋巴细胞占93%，其中66.3%为大颗粒淋巴细胞（LGL）。骨髓和淋巴结也被LGL浸润。表面标志物CD4、CD25和HLA-DR呈阳性，而CD3、CD8、CD16、CD56和CD57呈阴性。通过Southern印迹杂交分析在这些LGL上证实了HTLV-I前病毒DNA的单克隆整合。这一事实表明，一些成人T细胞白血病/淋巴瘤在形态学上可能表现为LGL白血病。