Meinnel T, Mechulam Y, Blanquet S
Laboratoire de Biochimie, URA-CNRS no 240, Palaiseau, France.
Biochimie. 1993;75(12):1061-75. doi: 10.1016/0300-9084(93)90005-d.
Methionine is the universal translation start but the first methionine is removed from most mature proteins. This review focuses on our present knowledge of the five enzymes sustaining the methionine pathway in translation initiation in Escherichia coli: methionyl-tRNA synthetase, methionyl-tRNA(fMet) formyltransferase, peptidyl-tRNA hydrolase, peptide deformylase and methionine aminopeptidase. The possible significance of retaining methionine as initiation signal is discussed.
甲硫氨酸是通用的翻译起始氨基酸，但大多数成熟蛋白质中的首个甲硫氨酸会被去除。本综述聚焦于我们目前对维持大肠杆菌翻译起始中甲硫氨酸途径的五种酶的认识：甲硫氨酰 - tRNA合成酶、甲硫氨酰 - tRNA(fMet) 甲酰基转移酶、肽基 - tRNA水解酶、肽脱甲酰基酶和甲硫氨酸氨肽酶。文中还讨论了保留甲硫氨酸作为起始信号的可能意义。
