有先兆和无先兆偏头痛患者血小板线粒体功能异常。

Abnormal platelet mitochondrial function in patients affected by migraine with and without aura.

作者信息

Sangiorgi S, Mochi M, Riva R, Cortelli P, Monari L, Pierangeli G, Montagna P

机构信息

Institute of Neurology, University of Bologna, Italy.

出版信息

Cephalalgia. 1994 Feb;14(1):21-3. doi: 10.1046/j.1468-2982.1994.1401021.x.

DOI:10.1046/j.1468-2982.1994.1401021.x

PMID:8200018

Abstract

To investigate energy metabolism in migraine, we determined platelet mitochondrial enzyme activities in 40 patients with migraine with aura and in 40 patients with migraine without aura during attack-free intervals and in 24 healthy control subjects. NADH-dehydrogenase, citrate synthase and cytochrome-c-oxidase activities in both patient groups were significantly lower than in controls (p < 0.01), while NADH-cytochrome-c-reductase activity was reduced only in migraine with aura (p < 0.01). No alteration in succinate-dehydrogenase was observed. Monoamine-oxidase activity differed between sexes (p < 0.05) but within each sex group no difference was observed between patients and controls. We hypothesize that the defect in mitochondrial enzymes observed indicates a systemic impairment of mitochondrial function in migraine patients.

摘要

为研究偏头痛中的能量代谢，我们测定了40例有先兆偏头痛患者、40例无先兆偏头痛患者在发作间期以及24名健康对照者的血小板线粒体酶活性。两组患者的NADH脱氢酶、柠檬酸合酶和细胞色素c氧化酶活性均显著低于对照组（p < 0.01），而NADH细胞色素c还原酶活性仅在有先兆偏头痛患者中降低（p < 0.01）。未观察到琥珀酸脱氢酶有改变。单胺氧化酶活性在性别之间存在差异（p < 0.05），但在每个性别组内，患者与对照组之间未观察到差异。我们推测，所观察到的线粒体酶缺陷表明偏头痛患者存在线粒体功能的系统性损害。