Kerr J R, O'Neill H J, Coyle P V, Thompson W
Royal Victoria Hospital, Belfast.
Ir J Med Sci. 1994 Feb;163(2):65-7. doi: 10.1007/BF02943018.
Eighty-five cases of B19 infection were diagnosed in Northern Ireland from 1984 to 1989; 65 of these occurred during 1989, the outbreak year. Of the total 85 cases, 15 had a rash, 21 had arthralgia, 47 had a rash and arthralgia, and 2 had aplastic crisis. The age range was 4-63 years with a mean of 26.9 years. Thirty cases (35%) were referred to hospital; 25 of these had arthralgia and 2 had aplastic crisis. Two thousand four hundred pregnant women at 12 weeks gestation in 1989 were screened for anti-B19 IgM; 8 were positive. Of these 8 patients, 7 progressed to delivery of a normal fetus and one had an intra-uterine death at 26 weeks gestation; no congenital abnormalities were noted in any fetus. The incidence of fetal involvement in maternal B19 infection in this study was therefore 12.5%.
1984年至1989年期间，北爱尔兰确诊了85例B19感染病例；其中65例发生在1989年疫情爆发之年。在这85例病例中，15例出现皮疹，21例有关节痛，47例既有皮疹又有关节痛，2例出现再生障碍危象。年龄范围为4至63岁，平均年龄为26.9岁。30例（35%）转诊至医院；其中25例有关节痛，2例出现再生障碍危象。1989年对2400名妊娠12周的孕妇进行了抗B19 IgM筛查；8例呈阳性。在这8例患者中，7例正常分娩胎儿，1例在妊娠26周时发生宫内死亡；所有胎儿均未发现先天性异常。因此，本研究中母亲B19感染累及胎儿的发生率为12.5%。
