人妊娠期间的细小病毒 B19 感染。
Parvovirus B19 infection in human pregnancy.
机构信息
Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, USA.
出版信息
BJOG. 2011 Jan;118(2):175-86. doi: 10.1111/j.1471-0528.2010.02749.x. Epub 2010 Oct 13.
Abstract
Human parvovirus B19 infection is widespread. Approximately 30-50% of pregnant women are nonimmune, and vertical transmission is common following maternal infection in pregnancy. Fetal infection may be associated with a normal outcome, but fetal death may also occur without ultrasound evidence of infectious sequelae. B19 infection should be considered in any case of nonimmune hydrops. Diagnosis is mainly through serology and polymerase chain reaction. Surveillance requires sequential ultrasound and Doppler screening for signs of fetal anaemia, heart failure and hydrops. Immunoglobulins, antiviral and vaccination are not yet available, but intrauterine transfusion in selected cases can be life saving.
摘要
人细小病毒 B19 感染广泛存在。大约 30-50%的孕妇为非免疫状态，母体妊娠期间感染后垂直传播较为常见。胎儿感染可能与正常结局相关，但也可能发生胎儿死亡，而无超声感染后遗症的证据。在任何非免疫性水肿的情况下都应考虑 B19 感染。诊断主要通过血清学和聚合酶链反应。监测需要连续的超声和多普勒筛查，以发现胎儿贫血、心力衰竭和水肿的迹象。免疫球蛋白、抗病毒药物和疫苗尚不可用，但在某些情况下，宫内输血可挽救生命。
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