Kojya S, Itokazu T, Maeshiro N, Esu H, Noda Y, Mishima K, Ohsawa M, Aozasa K
Department of Otorhinolaryngology, University of the Ryukyus Faculty of Medicine, Okinawa.
Jpn J Cancer Res. 1994 Apr;85(4):384-8. doi: 10.1111/j.1349-7006.1994.tb02371.x.
Lethal midline granuloma (LMG) is a clinical term used to describe a condition which may be manifested histologically as Wegener's granulomatosis (WG), polymorphic reticulosis (PR), and malignant lymphoma (ML). WG is an inflammatory disease, and PR and ML are considered to represent a neoplastic proliferation of lymphoreticular cells. In this report, twenty-two cases of LMG in Okinawa were examined. The frequency of LMG per 100,000 outpatients of the ear, nose and throat clinic in Okinawa was 67, and the higher frequency of PR (27) and ML (34) in Okinawa than in other districts of Japan was characteristic. Polymerase chain reaction, in situ hybridization, and immunohistochemical studies showed that the proliferating cells in PR were CD43+ and simultaneously contained Epstein-Barr viral genome in their nuclei. The higher frequency of PR and ML in Okinawa is discussed in conjunction with a review of pertinent literature: multiple factors including genetic, viral environmental, and socioeconomic factors seem to affect the frequencies of these diseases.
致死性中线肉芽肿（LMG）是一个临床术语，用于描述一种疾病状态，其组织学表现可能为韦格纳肉芽肿（WG）、多形性网状细胞增生症（PR）和恶性淋巴瘤（ML）。WG是一种炎症性疾病，而PR和ML被认为代表淋巴网状细胞的肿瘤性增殖。在本报告中，对冲绳地区的22例LMG病例进行了检查。冲绳地区耳鼻喉科门诊每10万名患者中LMG的发病率为67，冲绳地区PR（27例）和ML（34例）的发病率高于日本其他地区，这是其特点。聚合酶链反应、原位杂交和免疫组织化学研究表明，PR中的增殖细胞为CD43+，且细胞核中同时含有爱泼斯坦-巴尔病毒基因组。结合相关文献综述，讨论了冲绳地区PR和ML发病率较高的情况：包括遗传、病毒环境和社会经济因素在内的多种因素似乎影响这些疾病的发病率。
