2,4-二氨基甲苯在兔、大鼠和豚鼠体内的一些酚类代谢产物。
Some phenolic metabolites of 2, 4-diaminotoluene in the rabbit, rat and guinea-pig.
作者信息
Waring R H, Pheasant A E
出版信息
Xenobiotica. 1976 Apr;6(4):257-62. doi: 10.3109/00498257609151635.
PMID:820087
Abstract
- After administration of 2,4-diaminotoluene to rabbits, rats and guinea-pigs, phenolic metabolites are excreted, the major component being 5-hydroxy-2,4-diaminotoluene in all species investigated. Acetylated aminophenols and glucuronide conjugates were also found. 2. Rabbits, which produced the largest amounts of free amino-phenols, also had the highest levels of methaemoglobin in vivo.
摘要
- 给兔子、大鼠和豚鼠施用2,4 - 二氨基甲苯后，会排出酚类代谢物，在所研究的所有物种中，主要成分是5 - 羟基 - 2,4 - 二氨基甲苯。还发现了乙酰化氨基酚和葡糖醛酸共轭物。2. 产生大量游离氨基酚的兔子，其体内高铁血红蛋白水平也最高。
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