Davies M H, Harrison R F, Elias E, Hübscher S G
Birmingham Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.
J Hepatol. 1994 Jan;20(1):112-6. doi: 10.1016/s0168-8278(05)80476-3.
We report cases of amoxycillin- and flucloxacillin-induced liver damage associated with an acute vanishing bile duct syndrome. Ductopenia was present at the time of first liver biopsy, 3 weeks and 3 months after administration of the two drugs, respectively. Ductopenia apparently occurred as the primary lesion, with no evidence of accompanying portal tract inflammation. Subsequent biopsies showed a persistent paucity of ducts, accompanied by increasing features of chronic cholestasis. Biochemical dysfunction persists at 2 year's follow-up and late prognosis remains guarded.
我们报告了阿莫西林和氟氯西林引起的与急性胆管消失综合征相关的肝损伤病例。分别在服用这两种药物后3周和3个月进行首次肝活检时出现胆管减少。胆管减少显然是主要病变，没有伴随门静脉炎症的证据。随后的活检显示胆管持续稀少，并伴有慢性胆汁淤积的特征增加。在2年的随访中生化功能障碍持续存在，晚期预后仍不乐观。
