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N-omega-fluoroalkyl analogs of (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)-tropane (beta-CIT): radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters.

作者信息

Neumeyer J L, Wang S, Gao Y, Milius R A, Kula N S, Campbell A, Baldessarini R J, Zea-Ponce Y, Baldwin R M, Innis R B

机构信息

Research Biochemicals International, Natick, Massachusetts 01760.

出版信息

J Med Chem. 1994 May 27;37(11):1558-61. doi: 10.1021/jm00037a004.

DOI:10.1021/jm00037a004
PMID:8201589
Abstract
摘要

相似文献

1
N-omega-fluoroalkyl analogs of (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)-tropane (beta-CIT): radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters.(1R)-2β-甲氧羰基-3β-(4-碘苯基)-托烷（β-CIT）的N-ω-氟烷基类似物：用于多巴胺转运体正电子发射断层扫描和单光子发射计算机断层扫描成像的放射性示踪剂。
J Med Chem. 1994 May 27;37(11):1558-61. doi: 10.1021/jm00037a004.
2
Assessment of affinities of beta-CIT, beta-CIT-FE, and beta-CIT-FP for monoamine transporters permanently expressed in cell lines.评估β-CIT、β-CIT-FE和β-CIT-FP对在细胞系中稳定表达的单胺转运体的亲和力。
Nucl Med Biol. 1998 Jan;25(1):53-8. doi: 10.1016/s0969-8051(97)00156-x.
3
SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT.使用β-CIT的碘-123氟烷基类似物对人脑多巴胺转运体进行单光子发射计算机断层扫描（SPECT）成像。
J Nucl Med. 1996 Jul;37(7):1129-33.
4
Synthesis and characterization of radioiodinated N-(3-iodopropen-1-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl)tropanes: potential dopamine reuptake site imaging agents.放射性碘化的N-(3-碘代丙烯-1-基)-2β-甲氧羰基-3β-(4-氯苯基)托烷的合成与表征：潜在的多巴胺再摄取位点显像剂
J Med Chem. 1994 May 13;37(10):1535-42. doi: 10.1021/jm00036a020.
5
Iodine-123 labelled N-(2-fluoroethyl)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)nortropane for dopamine transporter imaging in the living human brain.用于活体人脑多巴胺转运体成像的碘-123标记的N-(2-氟乙基)-2β-甲氧羰基-3β-(4-碘苯基)降托烷
Eur J Nucl Med. 1995 Jul;22(7):682-6. doi: 10.1007/BF01254571.
6
Methyl 3 beta-(4-[125I]iodophenyl)tropane-2 beta-carboxylate in vitro binding to dopamine and serotonin transporters under "physiological" conditions.3β-(4-[¹²⁵I]碘苯基)托烷-2β-羧酸甲酯在“生理”条件下与多巴胺和5-羟色胺转运体的体外结合
J Neurochem. 1994 Mar;62(3):978-86. doi: 10.1046/j.1471-4159.1994.62030978.x.
7
Comparison of iodine-123 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and 2 beta-carbomethoxy-3 beta-(4-iodophenyl)-N-(3-fluoropropyl)nortropane for imaging of the dopamine transporter in the living human brain.用于活体人脑多巴胺转运体成像的碘-123标记的2β-甲氧羰基-3β-(4-碘苯基)托烷与2β-甲氧羰基-3β-(4-碘苯基)-N-(3-氟丙基)去甲托烷的比较
Eur J Nucl Med. 1995 Apr;22(4):356-60. doi: 10.1007/BF00941854.
8
Comparative in vivo study of iodine-123-labeled beta-CIT and nor-beta-CIT binding to serotonin transporters in rat brain.碘-123标记的β-CIT和去甲β-CIT与大鼠脑内5-羟色胺转运体结合的体内比较研究。
Synapse. 1999 Oct;34(1):77-80. doi: 10.1002/(SICI)1098-2396(199910)34:1<77::AID-SYN9>3.0.CO;2-Y.
9
Comparison of [123I]beta-CIT and [123I]IPCIT as single-photon emission tomography radiotracers for the dopamine transporter in nonhuman primates.[123I]β-CIT与[123I]IPCIT作为非人灵长类动物多巴胺转运体单光子发射断层显像放射性示踪剂的比较。
Eur J Nucl Med. 1995 Jan;22(1):4-11. doi: 10.1007/BF00997241.
10
3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters.可卡因的3-芳基-2-(3'-取代-1',2',4'-恶二唑-5'-基)托烷类似物：在多巴胺、5-羟色胺和去甲肾上腺素转运体的可卡因结合位点的亲和力
J Med Chem. 1993 Oct 1;36(20):2886-90. doi: 10.1021/jm00072a007.

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Single-site I-FP-CIT reference values from individuals with non-degenerative parkinsonism-comparison with values from healthy volunteers.
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Dtsch Arztebl Int. 2019 Nov 1;116(44):747-754. doi: 10.3238/arztebl.2019.0747.
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Degener Neurol Neuromuscul Dis. 2013 Jun 27;3:33-39. doi: 10.2147/DNND.S19807. eCollection 2013.
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