Nishimura T, Shimizu T, Mineo I, Kawachi M, Ono A, Nakajima H, Kuwajima M, Kono N, Matsuzawa Y
Second Department of Internal Medicine, Osaka University Medical School, Japan.
Metabolism. 1994 Jun;43(6):745-8. doi: 10.1016/0026-0495(94)90125-2.
We examined the influence of alcohol drinking habits on the serum uric acid level after the ingestion of a small amount of ethanol. Subjects were divided into two groups according to their alcohol drinking habits--regular drinkers, who consume more than 60 g ethanol every day, and nondrinkers/occasional drinkers, who consume less than 20 g ethanol occasionally. Drinking 0.5 g ethanol/kg increased serum uric acid levels in regular drinkers by 52.6 +/- 26.3 mumol/L (0.8 +/- 0.4 mg/dL), whereas it did not in nondrinkers/occasional drinkers. Urinary excretion of uric acid was unaltered in both groups. Hypoxanthine and xanthine in both plasma and urine and serum acetate were increased more in regular drinkers than in nondrinkers/occasional drinkers. Accelerated adenine nucleotide degradation secondary to enhanced ethanol oxidation likely explains the ethanol-induced hyperuricemia in regular drinkers.
我们研究了饮酒习惯对摄入少量乙醇后血清尿酸水平的影响。根据饮酒习惯将受试者分为两组——经常饮酒者，即每天摄入乙醇超过60克者，以及不饮酒者/偶尔饮酒者，即偶尔摄入乙醇少于20克者。每千克体重饮用0.5克乙醇使经常饮酒者的血清尿酸水平升高52.6±26.3微摩尔/升（0.8±0.4毫克/分升），而不饮酒者/偶尔饮酒者则未出现这种情况。两组的尿酸尿排泄均未改变。经常饮酒者血浆和尿液中的次黄嘌呤和黄嘌呤以及血清乙酸盐的增加幅度均大于不饮酒者/偶尔饮酒者。继发于乙醇氧化增强的腺嘌呤核苷酸加速降解可能解释了经常饮酒者中乙醇诱导的高尿酸血症。
