Ackland J R, Worswick D A, Marmion B P
CSL Ltd, Poplar Road, Parkville, Vic.
Med J Aust. 1994 Jun 6;160(11):704-8.
To examine the efficacy of various batches of a formalin-inactivated whole cell Coxiella burnetti vaccine (Henzerling strain, Phase 1 [Q-Vax, CSL]) in the prevention of Q fever among abattoir workers.
The study was a retrospective cohort survey of all employees at three South Australian abattoirs to determine the incidence of Q fever among vaccinated and unvaccinated employees during the period 1985 to 1990.
There were two cases of Q fever among 2555 vaccinated employees of the three abattoirs, compared with 55 cases among 1365 unvaccinated employees. The two Q fever cases in vaccinated employees were within a few days of vaccination, before immunity had developed, and represented a coincidence of natural infection and vaccination. Protective efficacy was 100%, even with a batch of Q-Vax containing 20 micrograms/dose rather than the standard dose of 30 micrograms/dose.
Vaccination was effective for at least five years, although it was uncertain whether this was due to the vaccine per se or to a combination of vaccine immunity reinforced by periodic natural exposure.
研究不同批次的福尔马林灭活全细胞伯纳特柯克斯体疫苗（亨泽林菌株，1期[Q-Vax，CSL]）在预防屠宰场工人Q热方面的效果。
该研究是对南澳大利亚三个屠宰场所有员工进行的回顾性队列调查，以确定1985年至1990年期间接种疫苗和未接种疫苗的员工中Q热的发病率。
三个屠宰场的2555名接种疫苗的员工中有2例Q热病例，而1365名未接种疫苗的员工中有55例。接种疫苗员工中的2例Q热病例发生在接种疫苗后的几天内，即在免疫力形成之前，是自然感染和接种疫苗的巧合。保护效力为100%，即使是一批每剂含20微克而非标准剂量30微克的Q-Vax也是如此。
疫苗接种至少在五年内有效，尽管不确定这是由于疫苗本身还是由于定期自然暴露增强了疫苗免疫力的综合作用。
